Sanctions are penalties imposed by countries or organizations against those who violate international regulations. OFAC regulates sanction programs to protect US national interests. Economic sanctions aim to prohibit US persons from conducting unauthorized business. US regulations apply to "US Persons" and transactions with a "US Nexus." Secondary sanctions target individuals, institutions, and citizens of third countries involved with sanctioned entities. OFAC has country-based comprehensive sanctions and list-based sanctions targeting specific individuals and institutions. Compliance with sanction regulations is essential, and companies should assess their export, end users, and purpose to ensure compliance.